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Bio-Specimen Platform Group

Kunishima Naoki (D.Sci.)
Group Director

To understand rationally the function of life activities, the 3D-structure of biological samples including proteins should be determined precisely at the atomic level. The X-ray crystallography is the most efficient and popular way to determine the atomic structure of biological samples to date. However, as a result of structural genomics, it was revealed that proteins which can crystallize were only 40% of all proteins from a thermo-stable microorganism. It is too hard to crystallize the rest 60% including membrane proteins by conventional technology. We will construct a high-throughput framework for the structure determination of challenging biological samples, through a complementary application of a new methodology based on XFEL and the technical basis of crystallography established in the Protein 3000 Project.





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